Drug Repositioning and Rescue for ALS

There are drugs that have been tested in humans for other conditions and shown to be safe that could work for ALS, but that have stalled on the way there. Sometimes the barrier is financial, sometimes scientific. This project identifies those compounds and their barriers to entry, reduces barriers, and accelerates these drugs into ALS clinical trials. It is the fastest path from a laboratory to a patient. Two drug candidates are currently in testing. Their identity will be revealed as the testing evolves.

What this project needs:

  • More drug candidates. If you know of a compound with an established safety record and a plausible reason to think it could help in ALS or FTD, we have the infrastructure to evaluate it and move it forward.


Several of these projects require funding, and the project needs for funds fluctuate. To donate to these efforts, please give to an unrestricted fund that is split evenly between End the Legacy and research projects driven towards curing genetic ALS/FTD.